Aggressive Breast Cancer Treatments Greensboro NC

The drug tamoxifen is a tried-and-true way to lower the chances of developing the most common type of recurrence among breast cancer survivors, but new research suggests it raises the risk of getting a more aggressive cancer in the healthy breast by more than four times.

Peter Rubin
(336) 832-1100
501 N Elam Ave
Greensboro, NC
Specialty
Internal Medicine, Medical Oncology

Data Provided by:
Kalsoom Kausar Khan
(336) 832-1100
501 N Elam Ave
Greensboro, NC
Specialty
Internal Medicine, Medical Oncology

Data Provided by:
Peter Robert Ennever
(336) 832-1100
501 N Elam Ave
Greensboro, NC
Specialty
Hematology, Hematology / Oncology, Medical Oncology

Data Provided by:
Matthew A Manning, MD
(336) 832-1100
501 N Elam Ave
Greensboro, NC
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Va Commonwealth Univ, Med Coll Of Va Sch Of Med, Richmond Va 23298
Graduation Year: 1996

Data Provided by:
Peter Rubin, MD
(336) 832-1100
501 N Elam Ave
Greensboro, NC
Specialties
Oncology (Cancer), Internal Medicine
Gender
Male
Education
Medical School: Univ Of Calgary, Fac Of Med, Calgary, Alb, Canada
Graduation Year: 1988

Data Provided by:
Lennis Pearcy Livesay, MD
(336) 832-1100
501 N Elam Ave
Greensboro, NC
Specialties
Oncology (Cancer)
Gender
Female
Education
Medical School: Univ Of Sc Sch Of Med, Columbia Sc 29208
Graduation Year: 1985

Data Provided by:
Lennis Pearcy Livesay
(336) 832-1100
501 N Elam Ave
Greensboro, NC
Specialty
Internal Medicine, Medical Oncology

Data Provided by:
James Mitchell Granfortuna
(336) 832-1100
501 N Elam Ave
Greensboro, NC
Specialty
Internal Medicine, Hematology / Oncology

Data Provided by:
Robert Murray
(336) 274-4285
1317 N Elm St
Greensboro, NC
Specialty
Radiation Oncology

Data Provided by:
Mohamed Kamel Mohamed
(336) 832-1100
501 N Elam Ave
Greensboro, NC
Specialty
Internal Medicine, Medical Oncology

Data Provided by:
Data Provided by:

Aggressive Breast Cancer Treatments

Provided By:

TUESDAY, Aug. 25 (HealthDay News) -- The drug tamoxifen is a tried-and-true way to lower the chances of developing the most common type of recurrence among breast cancer survivors, but new research suggests it raises the risk of getting a more aggressive cancer in the healthy breast by more than four times.

However, the finding is no reason to ditch the anti-cancer drug, as even the lead researcher emphasized.

"All treatments have risks and benefits," said study author Dr. Christopher Li, an associate member of the Fred Hutchinson Cancer Research Center in Seattle. "We know that the benefits of tamoxifen treatment clearly outweigh the risks. This study adds another risk, but doesn't change the overall balance. If you consider the full balance, for most women the benefits are going to far outweigh the risks."

Li and his colleagues evaluated tamoxifen use among 1,103 breast cancer survivors from the Seattle and Puget Sound area. The women were diagnosed initially with ER-positive breast cancer, the more common and less aggressive form, between the ages of 40 and 70.

Of those women, 369 developed a second breast cancer. Nearly all of those who took the hormonal therapy after surgery or other treatment used tamoxifen for five or more years. The researchers compared those who took tamoxifen with those who did not and found the drug, which blocks estrogen (which helps tumors grow) reduced ER-positive second breast cancers but boosted the risk of ER-negative tumors, which are less common but more aggressive.

"When we looked at the different types of second cancers, tamoxifen only lowered the risk of the more common and less aggressive type of cancer, ER-positive," Li said. "It lowered that by about 60 percent. But it increases the risk of developing ER-negative, the more aggressive cancer, by fourfold."

The study is published online Aug. 25 in the journal Cancer Research.

Exactly why the tamoxifen boosts the risk of ER-negative second cancers is not known, but Li said it could be that prolonged tamoxifen use provides "a competitive advantage for the growth of ER-negative breast cancer cells."

Other experts agreed that the study is no reason to give up on tamoxifen. "The thing we have to remember is tamoxifen saves lives," said Dr. Victor Vogel, national vice president of research at the American Cancer Society.

"Even though the risk of ER-negative goes up, only with five years or more, the risk of ER-positive [second breast cancer] goes down," he said. "We shouldn't lose sight of that."

"I worry people are going to panic if they are taking this drug," said Dr. Minetta Liu, director of translational breast cancer research at the Georgetown University Medical Center, in Washington, D.C. But they should not, she said, because "it has helped a huge number of women."

More information

To learn more about tamoxifen, visit the National Cancer Institute.

Author: By Kathleen Doheny
HealthDay Reporter

SOURCES: Victor Vogel, M.D., national vice president, research, American Cancer Society, Atlanta; Christopher Li, M.D., Ph.D., associate member, Fred Hutchinson Cancer Research Center, Seattle; Minetta Liu, M.D., director, translational breast cancer research, Georgetown University Medical Center, Washington, D.C.; August 25, 2009, Cancer Research

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com