Alzheimer's Gene in Young Adults Asheville NC

A gene variant linked to a higher risk of Alzheimer's disease seems to affect the brain when people are young, much earlier than previously thought, new research suggests. The brains of people in their mid-20s who had the gene variant known as APOE4 -- which boosts the risk of Alzheimer's but doesn't guarantee it -- seem to work differently than those of other people who don't have the gene, the researchers said.

Dennis Lee Martin, MD
(828) 255-7776
7 McDowell St
Asheville, NC
Specialties
Neurology
Gender
Male
Education
Medical School: Univ Of Va Sch Of Med, Charlottesville Va 22908
Graduation Year: 1965
Hospital
Hospital: Mission St Joseph Health Syste, Asheville, Nc
Group Practice: Mountain Neurological Center Pa

Data Provided by:
Duff Andrew Rardin, MD
(828) 252-6066
86 Victoria Rd Bldg A
Asheville, NC
Specialties
Neurology
Gender
Male
Education
Medical School: Bowman Gray Sch Of Med Of Wake Forest Univ, Winston-Salem Nc 27157
Graduation Year: 1986
Hospital
Hospital: Mission St Joseph Health Syste, Asheville, Nc; St Josephs Hospital, Asheville, Nc
Group Practice: Western Carolina Neurological

Data Provided by:
William M Huffstutter
(828) 252-8983
6 Brooklet St
Asheville, NC
Specialty
Neurology

Data Provided by:
Terence Barclay McGhee
(828) 253-7521
20 Mcdowell St
Asheville, NC
Specialty
Neurology

Data Provided by:
James Matthew Patton, MD
(828) 255-7776
7 McDowell St
Asheville, NC
Specialties
Neurology
Gender
Male
Education
Medical School: Emory Univ Sch Of Med, Atlanta Ga 30322
Graduation Year: 1989
Hospital
Hospital: Mission St Joseph Health Syste, Asheville, Nc
Group Practice: Mountain Neurological Center Pa

Data Provided by:
William M Huffstutter, MD
(828) 252-8983
6 Brooklet St
Asheville, NC
Specialties
Neurology
Gender
Male
Education
Medical School: Univ Of Tn, Memphis, Coll Of Med, Memphis Tn 38163
Graduation Year: 1977
Hospital
Hospital: Mission St Joseph Health Syste, Asheville, Nc

Data Provided by:
Reid Taylor
(828) 213-6600
509 Biltmore Ave
Asheville, NC
Specialty
Neurology

Data Provided by:
Michael H Young, MD
(828) 252-6066
86 Victoria Rd Bldg A
Asheville, NC
Specialties
Neurology
Gender
Male
Education
Medical School: Univ Of Nc At Chapel Hill Sch Of Med, Chapel Hill Nc 27599
Graduation Year: 1975

Data Provided by:
Alexander Schneider
(828) 213-6600
509 Biltmore Ave
Asheville, NC
Specialty
Neurology

Data Provided by:
Jonathan Douglas Sherman, MD
(828) 225-2608
7 Vanderbilt Park Dr
Asheville, NC
Specialties
Neurological Surgery
Gender
Male
Education
Medical School: In Univ Sch Of Med, Indianapolis In 46202
Graduation Year: 1995

Data Provided by:
Data Provided by:

Alzheimer's Gene in Young Adults

Provided By:

FRIDAY, Sept. 11 (HealthDay News) -- A gene variant linked to a higher risk of Alzheimer's disease seems to affect the brain when people are young, much earlier than previously thought, new research suggests.

The brains of people in their mid-20s who had the gene variant known as APOE4 -- which boosts the risk of Alzheimer's but doesn't guarantee it -- seem to work differently than those of other people who don't have the gene, the researchers said.

"While young people with and without the APOE4 gene had similar scores on a battery of memory tests, the brains of young people with the gene appear to be working harder or less efficiently to achieve the same results as people without the gene," study co-author Jeffrey Browndyke, director of the Functional Imaging Neurogenomics of Disease Lab at Duke University, said in a university news release.

The researchers looked at 24 healthy adults, 12 of whom had the gene variation. The volunteers took memory tests while their brains were being scanned with functional MRI.

"While all of the young adults performed similarly and their brains appeared the same, there are clear differences in brain activity and interconnection in people with the APOE4 gene that appear earlier in life than previously observed," Browndyke said. "We need to further explore the gene's effect on brain development and early cognitive function to determine who ultimately is at risk for Alzheimer's disease."

The findings were published online in the journal Alzheimer's & Dementia.

More information

Learn more about Alzheimer's from the Alzheimer's Association.

SOURCE: Duke University news release

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com