» » »

Alzheimer's Gene in Young Adults Durham NC

A gene variant linked to a higher risk of Alzheimer's disease seems to affect the brain when people are young, much earlier than previously thought, new research suggests. The brains of people in their mid-20s who had the gene variant known as APOE4 -- which boosts the risk of Alzheimer's but doesn't guarantee it -- seem to work differently than those of other people who don't have the gene, the researchers said.

Teesta B Soman, MD
Dumc 3936
Durham, NC
Specialties
Neurology
Gender
Female
Education
Medical School: Maulana Azad Med Coll, Univ Of Delhi, New Delhi, Delhi, India
Graduation Year: 1993

Data Provided by:
Aatif Mairaj Husain, MD
(919) 684-8485
Duke Univ Med Ctr #202
Durham, NC
Specialties
Neurology
Gender
Male
Education
Medical School: Rawalpindi Med Coll, Univ Of Punjab, Rawalpindi, Pakistan
Graduation Year: 1989

Data Provided by:
Ali Reza Zomorodi
(919) 684-8111
2100 Erwin Rd
Durham, NC
Specialty
Neurosurgery

Data Provided by:
Sean Shaiofong Hsu, MD
(919) 684-3309
Box 3841,
Durham, NC
Specialties
Neurological Surgery
Gender
Male
Education
Medical School: Univ Of Mi Med Sch, Ann Arbor Mi 48109
Graduation Year: 1986

Data Provided by:
Melvin Woodao Kong, MD
Division Of Neurology
Durham, NC
Specialties
Neurology
Gender
Male
Education
Medical School: Univ Of Calgary, Fac Of Med, Calgary, Alb, Canada
Graduation Year: 1994

Data Provided by:
Jeffrey Vance
(919) 620-4467
2100 Erwin Rd
Durham, NC
Specialty
Neurology

Data Provided by:
Lyman William Whitlatch, MD
(919) 684-3271
Box 3807,
Durham, NC
Specialties
Neurological Surgery
Gender
Male
Education
Medical School: Boston Univ Sch Of Med, Boston Ma 02118
Graduation Year: 2003

Data Provided by:
William C Gump, MD
(919) 684-3271
Box 3807,
Durham, NC
Gender
Male
Education
Medical School: Louisville
Graduation Year: 2001

Data Provided by:
Edward W Massey
(919) 620-4467
2100 Erwin Rd
Durham, NC
Specialty
Neurology

Data Provided by:
Ali R Zomorodi, MD
(919) 684-3271
Box 3807/Neurosurgery,
Durham, NC
Specialties
Neurological Surgery
Gender
Male
Education
Graduation Year: 2000

Data Provided by:
Data Provided by:

Alzheimer's Gene in Young Adults

Provided By:

FRIDAY, Sept. 11 (HealthDay News) -- A gene variant linked to a higher risk of Alzheimer's disease seems to affect the brain when people are young, much earlier than previously thought, new research suggests.

The brains of people in their mid-20s who had the gene variant known as APOE4 -- which boosts the risk of Alzheimer's but doesn't guarantee it -- seem to work differently than those of other people who don't have the gene, the researchers said.

"While young people with and without the APOE4 gene had similar scores on a battery of memory tests, the brains of young people with the gene appear to be working harder or less efficiently to achieve the same results as people without the gene," study co-author Jeffrey Browndyke, director of the Functional Imaging Neurogenomics of Disease Lab at Duke University, said in a university news release.

The researchers looked at 24 healthy adults, 12 of whom had the gene variation. The volunteers took memory tests while their brains were being scanned with functional MRI.

"While all of the young adults performed similarly and their brains appeared the same, there are clear differences in brain activity and interconnection in people with the APOE4 gene that appear earlier in life than previously observed," Browndyke said. "We need to further explore the gene's effect on brain development and early cognitive function to determine who ultimately is at risk for Alzheimer's disease."

The findings were published online in the journal Alzheimer's & Dementia.

More information

Learn more about Alzheimer's from the Alzheimer's Association.

SOURCE: Duke University news release

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com