Alzheimer's Gene in Young Adults Raleigh NC

A gene variant linked to a higher risk of Alzheimer's disease seems to affect the brain when people are young, much earlier than previously thought, new research suggests. The brains of people in their mid-20s who had the gene variant known as APOE4 -- which boosts the risk of Alzheimer's but doesn't guarantee it -- seem to work differently than those of other people who don't have the gene, the researchers said.

Traci Elizabeth Irwin, MD
Raleigh, NC
Specialties
Neurology
Gender
Female
Education
Medical School: Univ Of Nc At Chapel Hill Sch Of Med, Chapel Hill Nc 27599
Graduation Year: 1998

Data Provided by:
A Thomas Perkins IV, MD
(919) 782-3456
1540 Sunday Dr
Raleigh, NC
Specialties
Neurology, Sleep Medicine
Gender
Male
Education
Medical School: Northeastern Oh Univs Coll Of Med, Rootstown Oh 44272
Graduation Year: 1991
Hospital
Hospital: Rex Healthcare, Raleigh, Nc; Wake Med Ctr, Raleigh, Nc
Group Practice: Carnes, Kenneth M Phd

Data Provided by:
Steven Mitchell Freedman, MD
(919) 782-3456
1540 Sunday Dr
Raleigh, NC
Specialties
Neurology
Gender
Male
Education
Medical School: Univ Of Pa Sch Of Med, Philadelphia Pa 19104
Graduation Year: 1972
Hospital
Hospital: Wake Med Ctr, Raleigh, Nc
Group Practice: Raleigh Neurology Assocs

Data Provided by:
Kim Livingston, MD
(919) 785-3400
3700 Barrett Dr
Raleigh, NC
Specialties
Neurological Surgery
Gender
Female
Education
Medical School: Med Univ Of Sc Coll Of Med, Charleston Sc 29425
Graduation Year: 1985

Data Provided by:
Robert Lee Allen, MD
(919) 785-3400
3700 Barrett Dr
Raleigh, NC
Specialties
Neurological Surgery
Gender
Male
Education
Medical School: Bowman Gray Sch Of Med Of Wake Forest Univ, Winston-Salem Nc 27157
Graduation Year: 1979

Data Provided by:
Gregory Michael Bertics, MD
(919) 855-0335
3400 Executive Dr Ste 201
Raleigh, NC
Specialties
Neurology
Gender
Male
Education
Medical School: Duke Univ Sch Of Med, Durham Nc 27710
Graduation Year: 1982
Hospital
Hospital: Wake Med Ctr, Raleigh, Nc; Raleigh Community Hospital, Raleigh, Nc
Group Practice: Raleigh Neurology Assocs

Data Provided by:
Jeffrey Siegel, MD
(919) 734-9888
Raleigh, NC
Specialties
Neurology, Physical Medicine And Rehabilitation
Gender
Male
Education
Medical School: Suny At Stony Brook Hlth Sci Ctr, Stony Brook Ny 11794
Graduation Year: 1989

Data Provided by:
Patricia Keogh Naslund, MD
(919) 782-3456
1540 Sunday Dr
Raleigh, NC
Specialties
Neurology
Gender
Female
Education
Medical School: Duke Univ Sch Of Med, Durham Nc 27710
Graduation Year: 1994

Data Provided by:
Steven M Freedman
(919) 782-3456
1540 Sunday Dr
Raleigh, NC
Specialty
Neurology

Data Provided by:
Dr.Rhonda Gabr
(919) 782-3456
1540 Sunday Drive
Raleigh, NC
Gender
F
Education
Medical School: Wv Univ Sch Of Med
Year of Graduation: 1998
Speciality
Neurologist
General Information
Hospital: Raleigh Neurology
Online Appt Scheduling: Yes
Accepting New Patients: Yes
RateMD Rating
4.9, out of 5 based on 7, reviews.

Data Provided by:
Data Provided by:

Alzheimer's Gene in Young Adults

Provided By:

FRIDAY, Sept. 11 (HealthDay News) -- A gene variant linked to a higher risk of Alzheimer's disease seems to affect the brain when people are young, much earlier than previously thought, new research suggests.

The brains of people in their mid-20s who had the gene variant known as APOE4 -- which boosts the risk of Alzheimer's but doesn't guarantee it -- seem to work differently than those of other people who don't have the gene, the researchers said.

"While young people with and without the APOE4 gene had similar scores on a battery of memory tests, the brains of young people with the gene appear to be working harder or less efficiently to achieve the same results as people without the gene," study co-author Jeffrey Browndyke, director of the Functional Imaging Neurogenomics of Disease Lab at Duke University, said in a university news release.

The researchers looked at 24 healthy adults, 12 of whom had the gene variation. The volunteers took memory tests while their brains were being scanned with functional MRI.

"While all of the young adults performed similarly and their brains appeared the same, there are clear differences in brain activity and interconnection in people with the APOE4 gene that appear earlier in life than previously observed," Browndyke said. "We need to further explore the gene's effect on brain development and early cognitive function to determine who ultimately is at risk for Alzheimer's disease."

The findings were published online in the journal Alzheimer's & Dementia.

More information

Learn more about Alzheimer's from the Alzheimer's Association.

SOURCE: Duke University news release

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com