Alzheimer's Gene in Young Adults Winston Salem NC

A gene variant linked to a higher risk of Alzheimer's disease seems to affect the brain when people are young, much earlier than previously thought, new research suggests. The brains of people in their mid-20s who had the gene variant known as APOE4 -- which boosts the risk of Alzheimer's but doesn't guarantee it -- seem to work differently than those of other people who don't have the gene, the researchers said.

Charles Edward Rawlings, MD
(336) 724-4755
407 Summit St
Winston Salem, NC
Specialties
Neurological Surgery
Gender
Male
Education
Medical School: Duke Univ Sch Of Med, Durham Nc 27710
Graduation Year: 1982

Data Provided by:
Thomas Allen Sweasey, MD
(336) 714-0263
175 Kimel Park Dr Ste 100
Winston Salem, NC
Specialties
Neurological Surgery
Gender
Male
Education
Medical School: Univ Of Cincinnati Coll Of Med, Cincinnati Oh 45267
Graduation Year: 1985
Hospital
Hospital: Iredell Memorial Hospital, Statesville, Nc
Group Practice: Carolina Neurosurgical Assoc

Data Provided by:
William Alex Brady, MD
(336) 659-7990
250 Executive Park Blvd
Winston Salem, NC
Specialties
Neurology
Gender
Male
Education
Medical School: Bowman Gray Sch Of Med Of Wake Forest Univ, Winston-Salem Nc 27157
Graduation Year: 1970

Data Provided by:
John Baldwin Smith
(978) 536-7400
160 Charlois Blvd
Winston Salem, NC
Specialty
Neurology

Data Provided by:
Joseph T Alexander, MD
(336) 716-6437
Medical Center Dr
Winston-Salem, NC
Specialties
Neurological Surgery, Orthopedic Surgery Of The Spine
Gender
Male
Education
Medical School: Columbia Univ Coll Of Physicians And Surgeons, New York Ny 10032
Graduation Year: 1985

Data Provided by:
Travis Harold Jackson, MD
(336) 768-6347
175 Kimel Park Dr Ste 125
Winston Salem, NC
Specialties
Neurology
Gender
Male
Education
Medical School: Baylor Coll Of Med, Houston Tx 77030
Graduation Year: 1975

Data Provided by:
William Beall Lorentz
(336) 716-2255
Medical Center Blvd
Winston Salem, NC
Specialty
Neurology

Data Provided by:
Kerstin Bettermann, MD
(919) 716-2011
300 S Hawthorne Rd
Winston Salem, NC
Specialties
Neurology
Gender
Female
Education
Medical School: Ruprecht-Karl-Univ, Med Fak, Heidelberg, Germany (407-10 Pr 1/71)
Graduation Year: 1996

Data Provided by:
Mark Andrew Lyerly, MD
(336) 794-0057
145 Kimel Park Dr Ste 220
Winston Salem, NC
Specialties
Neurological Surgery
Gender
Male
Education
Medical School: Duke Univ Sch Of Med, Durham Nc 27710
Graduation Year: 1988

Data Provided by:
Diana Lynn Greene-Chandos
(336) 277-2200
2025 Frontis Plaza Blvd
Winston-Salem, NC
Specialty
Neurology

Data Provided by:
Data Provided by:

Alzheimer's Gene in Young Adults

Provided By:

FRIDAY, Sept. 11 (HealthDay News) -- A gene variant linked to a higher risk of Alzheimer's disease seems to affect the brain when people are young, much earlier than previously thought, new research suggests.

The brains of people in their mid-20s who had the gene variant known as APOE4 -- which boosts the risk of Alzheimer's but doesn't guarantee it -- seem to work differently than those of other people who don't have the gene, the researchers said.

"While young people with and without the APOE4 gene had similar scores on a battery of memory tests, the brains of young people with the gene appear to be working harder or less efficiently to achieve the same results as people without the gene," study co-author Jeffrey Browndyke, director of the Functional Imaging Neurogenomics of Disease Lab at Duke University, said in a university news release.

The researchers looked at 24 healthy adults, 12 of whom had the gene variation. The volunteers took memory tests while their brains were being scanned with functional MRI.

"While all of the young adults performed similarly and their brains appeared the same, there are clear differences in brain activity and interconnection in people with the APOE4 gene that appear earlier in life than previously observed," Browndyke said. "We need to further explore the gene's effect on brain development and early cognitive function to determine who ultimately is at risk for Alzheimer's disease."

The findings were published online in the journal Alzheimer's & Dementia.

More information

Learn more about Alzheimer's from the Alzheimer's Association.

SOURCE: Duke University news release

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com