Breast Cancer Prognosis Asheville NC

Two new studies have found that levels of the protein caveolin-1 found in stromal connective tissue near a breast cancer tumor can accurately predict a patient's prognosis and may provide a pathway to future treatments in Asheville.

Brian Patrick Quaranta, MD
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445 Biltmore Ave
Asheville, NC
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Oncology (Cancer), Radiation Oncology
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Medical School: Umdnj-New Jersey Med Sch, Newark Nj 07103
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Don Vernon Jackson Jr, MD
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Medical School: Univ Of Va Sch Of Med, Charlottesville Va 22908
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Michael Joseph Messino, MD
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Asheville, NC
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Medical School: Oh State Univ Coll Of Med, Columbus Oh 43210
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Hospital: Haywood Reg Med Ctr, Clyde, Nc; Spruce Pine Community Hospital, Spruce Pine, Nc; St Josephs Hospital, Asheville, Nc
Group Practice: Cancer Care

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Orren Beaty III, DO
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Medical School: Kirksville Coll Of Osteo Med, Kirksville Mo 63501
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Orren Beaty, DO
(828) 213-5770
50 Doctors Dr
Asheville, NC
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Medical School: Kirksville Coll Of Osteo Med, Kirksville Mo 63501
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Wieslawa A Pekal
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Paul Langlie Martin, MD
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Medical School: Washington Univ Sch Of Med, St Louis Mo 63110
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Quinten C Black
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Shantae Ladon Lucas
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Hematology / Oncology, Medical Oncology

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Wieslawa Pekal, MD
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Asheville, NC
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Oncology (Cancer)
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Medical School: Suny-Hlth Sci Ctr At Brooklyn, Coll Of Med, Brooklyn Ny 11203
Graduation Year: 1990
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Hospital: Haywood Reg Med Ctr, Clyde, Nc
Group Practice: Cancer Care Of Western North Carolina

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Breast Cancer Prognosis

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FRIDAY, May 22 (HealthDay News) -- Two new studies have found that levels of the protein caveolin-1 found in stromal connective tissue near a breast cancer tumor can accurately predict a patient's prognosis and may provide a pathway to future treatments.

Low levels of caveolin-1, which plays a role in how cells absorb things, in the stromal cells were linked to a poor patient outcome in a study by Dr. Agnieszka K. Witkiewicz, from Thomas Jefferson University in Philadelphia, and colleagues. The findings are published in the June issue of the American Journal of Pathology.

The second study, in the same issue of the journal, found that a similar lack of stromal caveolin-1 in mice was associated with more aggressive tumor growth in the rodents, according to Erica K. Sloan, from the Peter MacCallum Cancer Centre in East Melbourne, Australia, and colleagues.

The findings led Sloan's research team to hypothesize that caveolin-1 may work as a tumor suppressant, at least in stromal tissue.

"These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression," Sloan and colleagues concluded in their report.

Previous research had found that caveolin-1 plays a big part in the development of breast cancer tumors, according to a news release from the journal.

More information

The American Cancer Society has more about breast cancer.

SOURCE: American Journal of Pathology, news release, May 22, 2009

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