Breast Cancer Prognosis Camp Lejeune NC

Two new studies have found that levels of the protein caveolin-1 found in stromal connective tissue near a breast cancer tumor can accurately predict a patient's prognosis and may provide a pathway to future treatments in Camp Lejeune.

Susan Kidwell Williford, MD
(336) 802-2500
302 Westwood Ave
High Point, NC
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Oncology (Cancer)
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Medical School: Bowman Gray Sch Of Med Of Wake Forest Univ, Winston-Salem Nc 27157
Graduation Year: 1984

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David L Meta
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Rocky Mount, NC
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Hematology / Oncology

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Gary Herbert Lyman
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2100 Erwin Rd
Durham, NC
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Hematology / Oncology, Medical Oncology

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Anthony J Crimaldi
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Charlotte, NC
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Radiation Oncology

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Ron Russell Allison, MD
(716) 838-5933
Greenville, NC
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Oncology (Cancer), Radiation Oncology
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Medical School: Suny-Hlth Sci Ctr At Brooklyn, Coll Of Med, Brooklyn Ny 11203
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John C Huffman
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901 N Winstead Ave
Rocky Mount, NC
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Kenneth Dale Zeitler, MD
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Raleigh, NC
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Oncology (Cancer)
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Medical School: Columbia Univ Coll Of Physicians And Surgeons, New York Ny 10032
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John Hugh Bryan, MD
(910) 609-6690
PO Box 41208
Fayetteville, NC
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Medical School: Univ Of Nc At Chapel Hill Sch Of Med, Chapel Hill Nc 27599
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Hospital: Cape Fear Valley Med Center, Fayetteville, Nc; Southeastern Reg Med Ctr, Lumberton, Nc
Group Practice: South East Radiation Oncology

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Matthew A Manning, MD
(336) 832-1100
501 N Elam Ave
Greensboro, NC
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Oncology (Cancer), Radiation Oncology
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Medical School: Va Commonwealth Univ, Med Coll Of Va Sch Of Med, Richmond Va 23298
Graduation Year: 1996

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Carlos M De Castro, MD
(919) 684-8964
Chapel Hill, NC
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Oncology (Cancer), Internal Medicine
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Medical School: Univ Of Tx Southwestern Med Ctr At Dallas, Med Sch, Dallas Tx 75235
Graduation Year: 1985

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Breast Cancer Prognosis

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FRIDAY, May 22 (HealthDay News) -- Two new studies have found that levels of the protein caveolin-1 found in stromal connective tissue near a breast cancer tumor can accurately predict a patient's prognosis and may provide a pathway to future treatments.

Low levels of caveolin-1, which plays a role in how cells absorb things, in the stromal cells were linked to a poor patient outcome in a study by Dr. Agnieszka K. Witkiewicz, from Thomas Jefferson University in Philadelphia, and colleagues. The findings are published in the June issue of the American Journal of Pathology.

The second study, in the same issue of the journal, found that a similar lack of stromal caveolin-1 in mice was associated with more aggressive tumor growth in the rodents, according to Erica K. Sloan, from the Peter MacCallum Cancer Centre in East Melbourne, Australia, and colleagues.

The findings led Sloan's research team to hypothesize that caveolin-1 may work as a tumor suppressant, at least in stromal tissue.

"These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression," Sloan and colleagues concluded in their report.

Previous research had found that caveolin-1 plays a big part in the development of breast cancer tumors, according to a news release from the journal.

More information

The American Cancer Society has more about breast cancer.

SOURCE: American Journal of Pathology, news release, May 22, 2009

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