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Breast Cancer Prognosis Durham NC

Two new studies have found that levels of the protein caveolin-1 found in stromal connective tissue near a breast cancer tumor can accurately predict a patient's prognosis and may provide a pathway to future treatments in Durham.

Douglas Rivera, MD
Durham, NC
Specialties
Oncology (Cancer)
Gender
Male
Education
Graduation Year: 2007

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Rebekah Ruth White
(919) 684-8111
2100 Erwin Rd
Durham, NC
Specialty
General Surgery, Surgical Oncology

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Stephan Disean Kendall, MD
(919) 684-8111
Erwin Rd Box 3841,
Durham, NC
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Albany Med Coll, Albany Ny 12208
Graduation Year: 1999

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Louis F Diehl, MD
(919) 684-8964
Box 3872,
Durham, NC
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Georgetown Univ Sch Of Med, Washington Dc 20007
Graduation Year: 1975

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Joseph Odell Moore, MD
(919) 684-8964
PO Box 3872,
Durham, NC
Specialties
Oncology (Cancer), Internal Medicine
Gender
Male
Education
Medical School: Johns Hopkins Univ Sch Of Med, Baltimore Md 21205
Graduation Year: 1970
Hospital
Hospital: Duke University Med Ctr, Durham, Nc; Veterans Affairs Med Ctr, Durham, Nc

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James R Oleson, MD, PHD
(919) 668-7336
PO Box 3085 DUMC,
Durham, NC
Specialties
Oncology (Cancer)
Gender
Male
Education
Graduation Year: 2007

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Shiaowen David Hsu
(919) 684-8111
2100 Erwin Rd
Durham, NC
Specialty
Hematology / Oncology

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Laura M Decastro, MD
(919) 684-6464
Erwin Road,
Durham, NC
Specialties
Oncology (Cancer)
Gender
Female
Education
Medical School: Univ Auto De Santo Domingo (Uasd), Fac De Cien Med, Santo Domingo
Graduation Year: 1986

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Gowthami Arepally
(919) 620-4467
Duke University Medical Ctr
Durham, NC
Specialty
Hematology

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Sandeep S Dave
(919) 684-8111
2100 Erwin Rd
Durham, NC
Specialty
Internal Medicine, Hematology / Oncology

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Breast Cancer Prognosis

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FRIDAY, May 22 (HealthDay News) -- Two new studies have found that levels of the protein caveolin-1 found in stromal connective tissue near a breast cancer tumor can accurately predict a patient's prognosis and may provide a pathway to future treatments.

Low levels of caveolin-1, which plays a role in how cells absorb things, in the stromal cells were linked to a poor patient outcome in a study by Dr. Agnieszka K. Witkiewicz, from Thomas Jefferson University in Philadelphia, and colleagues. The findings are published in the June issue of the American Journal of Pathology.

The second study, in the same issue of the journal, found that a similar lack of stromal caveolin-1 in mice was associated with more aggressive tumor growth in the rodents, according to Erica K. Sloan, from the Peter MacCallum Cancer Centre in East Melbourne, Australia, and colleagues.

The findings led Sloan's research team to hypothesize that caveolin-1 may work as a tumor suppressant, at least in stromal tissue.

"These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression," Sloan and colleagues concluded in their report.

Previous research had found that caveolin-1 plays a big part in the development of breast cancer tumors, according to a news release from the journal.

More information

The American Cancer Society has more about breast cancer.

SOURCE: American Journal of Pathology, news release, May 22, 2009

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