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Breast Cancer Prognosis Durham NC

Two new studies have found that levels of the protein caveolin-1 found in stromal connective tissue near a breast cancer tumor can accurately predict a patient's prognosis and may provide a pathway to future treatments in Durham.

Douglas Rivera, MD
Durham, NC
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Oncology (Cancer)
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Male
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Graduation Year: 2007

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Jeffrey Crawford
(919) 620-4467
Duke University Medical Ctr
Durham, NC
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Hematology / Oncology, Medical Oncology

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John Falletta
(919) 620-4467
2100 Erwin Rd
Durham, NC
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Hematology / Oncology

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Ngocdiep Thi Le, MD
(919) 681-6816
3829 Duke South Red Zone DUMC 3841,
Durham, NC
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Oncology (Cancer)
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Female
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Medical School: Stanford Univ Sch Of Med, Stanford Ca 94305
Graduation Year: 2000

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Michael Aaron Morse, MD
(919) 681-3480
Box 3233,
Durham, NC
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Oncology (Cancer)
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Male
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Medical School: Yale Univ Sch Of Med, New Haven Ct 06510
Graduation Year: 1990

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Philip Paul Breitfeld, MD
(919) 684-3401
Ped Hematol-Oncol Box 2916,
Durham, NC
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Oncology (Cancer)
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Male
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Medical School: Univ Of Rochester Sch Of Med & Dentistry, Rochester Ny 14642
Graduation Year: 1979

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Andrew Berchuck, MD
(919) 684-3765
PO Box 3079,
Durham, NC
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Oncology (Cancer), Gynecological Oncology
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Male
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Medical School: Case Western Reserve Univ Sch Of Med, Cleveland Oh 44106
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Corinne Linardic
(919) 620-4467
2100 Erwin Rd
Durham, NC
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Hematology / Oncology

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Sam O Wanko, MD
(919) 684-2287
DUMC 3841 3829 Duke South Red Zone,
Durham, NC
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Oncology (Cancer)
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Male
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Medical School: Univ Of Va Sch Of Med, Charlottesville Va 22908
Graduation Year: 1997

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Gordana Vlahovic, MD
PO Box 3335 Rm 25164,
Durham, NC
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Medical School: Univ Of Zagreb, Med Fak, Zagreb, Croatia
Graduation Year: 1987

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Breast Cancer Prognosis

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FRIDAY, May 22 (HealthDay News) -- Two new studies have found that levels of the protein caveolin-1 found in stromal connective tissue near a breast cancer tumor can accurately predict a patient's prognosis and may provide a pathway to future treatments.

Low levels of caveolin-1, which plays a role in how cells absorb things, in the stromal cells were linked to a poor patient outcome in a study by Dr. Agnieszka K. Witkiewicz, from Thomas Jefferson University in Philadelphia, and colleagues. The findings are published in the June issue of the American Journal of Pathology.

The second study, in the same issue of the journal, found that a similar lack of stromal caveolin-1 in mice was associated with more aggressive tumor growth in the rodents, according to Erica K. Sloan, from the Peter MacCallum Cancer Centre in East Melbourne, Australia, and colleagues.

The findings led Sloan's research team to hypothesize that caveolin-1 may work as a tumor suppressant, at least in stromal tissue.

"These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression," Sloan and colleagues concluded in their report.

Previous research had found that caveolin-1 plays a big part in the development of breast cancer tumors, according to a news release from the journal.

More information

The American Cancer Society has more about breast cancer.

SOURCE: American Journal of Pathology, news release, May 22, 2009

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