Breast Cancer Prognosis Greensboro NC

Two new studies have found that levels of the protein caveolin-1 found in stromal connective tissue near a breast cancer tumor can accurately predict a patient's prognosis and may provide a pathway to future treatments in Greensboro.

Justin Ja-Li Wu, MD
(336) 832-1100
501 N Elam Ave
Greensboro, NC
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Oncology (Cancer), Radiation Oncology
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Medical School: Duke Univ Sch Of Med, Durham Nc 27710
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James Mitchell Granfortuna
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Greensboro, NC
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Internal Medicine, Hematology / Oncology

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Lennis Pearcy Livesay, MD
(336) 832-1100
501 N Elam Ave
Greensboro, NC
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Oncology (Cancer)
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Medical School: Univ Of Sc Sch Of Med, Columbia Sc 29208
Graduation Year: 1985

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Lennis Pearcy Livesay
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501 N Elam Ave
Greensboro, NC
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Internal Medicine, Medical Oncology

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Peter Robert Ennever, MD
(336) 832-1100
501 N Elam Ave
Greensboro, NC
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Medical School: George Washington Univ Sch Of Med & Hlth Sci, Washington Dc 20037
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Firas N Shadad
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501 N Elam Ave
Greensboro, NC
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Robert Murray
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1317 N Elm St
Greensboro, NC
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Radiation Oncology

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Kalsoom Kausar Khan
(336) 832-1100
501 N Elam Ave
Greensboro, NC
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Gustav Charles Magrinat
(336) 832-1100
501 N Elam Ave
Greensboro, NC
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Internal Medicine, Hematology / Oncology

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John Emerson Feldmann, MD
(336) 832-0820
501 N Elam Ave
Greensboro, NC
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Oncology (Cancer), Hematology-Internal Medicine
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Medical School: Cornell Univ Med Coll, New York Ny 10021
Graduation Year: 1968

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Breast Cancer Prognosis

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FRIDAY, May 22 (HealthDay News) -- Two new studies have found that levels of the protein caveolin-1 found in stromal connective tissue near a breast cancer tumor can accurately predict a patient's prognosis and may provide a pathway to future treatments.

Low levels of caveolin-1, which plays a role in how cells absorb things, in the stromal cells were linked to a poor patient outcome in a study by Dr. Agnieszka K. Witkiewicz, from Thomas Jefferson University in Philadelphia, and colleagues. The findings are published in the June issue of the American Journal of Pathology.

The second study, in the same issue of the journal, found that a similar lack of stromal caveolin-1 in mice was associated with more aggressive tumor growth in the rodents, according to Erica K. Sloan, from the Peter MacCallum Cancer Centre in East Melbourne, Australia, and colleagues.

The findings led Sloan's research team to hypothesize that caveolin-1 may work as a tumor suppressant, at least in stromal tissue.

"These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression," Sloan and colleagues concluded in their report.

Previous research had found that caveolin-1 plays a big part in the development of breast cancer tumors, according to a news release from the journal.

More information

The American Cancer Society has more about breast cancer.

SOURCE: American Journal of Pathology, news release, May 22, 2009

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