Cancer-Causing Proteins Asheville NC

The drugs, called thiazole antibiotics, appear to block a cellular protein called FoxM1, one of the most over-produced proteins in cancer cells, according to researchers at the University of Illinois at Chicago College of Medicine. FoxM1 is believed to play an important role in causing cells to become cancerous and may present a promising target for future anti-cancer treatments.

Quinten Curtis Black, MD
(828) 253-7077
445 Biltmore Ave Ste G102
Asheville, NC
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Tulane Univ Sch Of Med, New Orleans La 70112
Graduation Year: 1998

Data Provided by:
Wieslawa A Pekal
(828) 253-4262
445 Biltmore Ave
Asheville, NC
Specialty
Hematology / Oncology, Medical Oncology

Data Provided by:
Krystal Dawn Sanchez, MD
50 Doctors Dr Ste 105
Asheville, NC
Specialties
Oncology (Cancer)
Gender
Female
Education
Medical School: Univ Of Fl Coll Of Med, Gainesville Fl 32610
Graduation Year: 1989

Data Provided by:
Eric Ford Kuehn, MD
(828) 254-1111
90 Asheland Ave
Asheville, NC
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Med Coll Of Ga Sch Of Med, Augusta Ga 30912
Graduation Year: 1990
Hospital
Hospital: Margaret R Pardee Memorial Hos, Hendersonvlle, Nc
Group Practice: Mountain Radiation Oncology Pa

Data Provided by:
Shantae Ladon Lucas, MD
(828) 253-4262
445 Biltmore Ave Ste 100
Asheville, NC
Specialties
Oncology (Cancer)
Gender
Female
Education
Medical School: Univ Of Ky Coll Of Med, Lexington Ky 40536
Graduation Year: 1991

Data Provided by:
Barton Riley Paschal, MD
(828) 254-8232
1 Doctors Dr
Asheville, NC
Specialties
Oncology (Cancer), Hematology-Internal Medicine
Gender
Male
Education
Medical School: Emory Univ Sch Of Med, Atlanta Ga 30322
Graduation Year: 1976
Hospital
Hospital: Park Ridge Hospital, Fletcher, Nc; Mission St Joseph Health Syste, Asheville, Nc; St Josephs Hospital, Asheville, Nc
Group Practice: Asheville Hematology Oncology Assoc Pa; Asheville Hematology Oncology Associates Pa

Data Provided by:
Christopher Haekang Chay
(828) 253-4262
445 Biltmore Ave
Asheville, NC
Specialty
Hematology / Oncology, Medical Oncology

Data Provided by:
Don Vernon Jackson Jr, MD
(828) 254-8232
1 Doctors Dr
Asheville, NC
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Univ Of Va Sch Of Med, Charlottesville Va 22908
Graduation Year: 1972

Data Provided by:
Orren Beaty, DO
(828) 213-5770
50 Doctors Dr
Asheville, NC
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Kirksville Coll Of Osteo Med, Kirksville Mo 63501
Graduation Year: 1988

Data Provided by:
Mohan Chand Thakuri
(828) 253-4262
445 Biltmore Ave
Asheville, NC
Specialty
Hematology / Oncology

Data Provided by:
Data Provided by:

Cancer-Causing Proteins

Provided By:

Scientists are closer to understanding how a recently approved class of antibiotics may work against cancer.

The drugs, called thiazole antibiotics, appear to block a cellular protein called FoxM1, one of the most over-produced proteins in cancer cells, according to researchers at the University of Illinois at Chicago College of Medicine. FoxM1 is believed to play an important role in causing cells to become cancerous and may present a promising target for future anti-cancer treatments.

The researchers also found that thiazoles may inhibit proteasomes, a molecular complex within cells that disposes of old proteins marked for destruction. Recently, a number of proteasome inhibitors have shown promise against cancer. One of these inhibitors, bortezomib (Velcade), has proven effective against a number of cancers, including myeloma and certain forms of lymphoma.

The new research, which appears in the online journal PLoS ONE, points to the possible anti-cancer use of thiazoles in the future. In a university news release, study author Andrei Gartel, an associate professor of molecular genetics, said that by using thiazole antibiotics in combination with well-known proteasome inhibitors, "we may see a synergy that allows us to markedly reduce the dose of any one of these drugs and still effectively kill the cancer cells."

More information

Read more about cancer treatments at the U.S. National Cancer Institute.

SOURCE: University of Illinois at Chicago, news release, Aug. 11, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com