Cancer-Causing Proteins Charlotte NC

The drugs, called thiazole antibiotics, appear to block a cellular protein called FoxM1, one of the most over-produced proteins in cancer cells, according to researchers at the University of Illinois at Chicago College of Medicine. FoxM1 is believed to play an important role in causing cells to become cancerous and may present a promising target for future anti-cancer treatments.

Timothy Earl Cloninger, MD
(704) 333-7376
200 Queens Rd
Charlotte, NC
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Univ Of Nc At Chapel Hill Sch Of Med, Chapel Hill Nc 27599
Graduation Year: 1966
Hospital
Hospital: Rowan Reg Med Ctr, Salisbury, Nc; Carolinas Med Ctr, Charlotte, Nc
Group Practice: Southeast Radiation Oncology Group Matthews Rad Oncology; Southeast Radiation Oncology Group Pa; Southeast Radiation Oncology Group Rock Hill Rad Oncology; Sou

Data Provided by:
Thomas Gary Trautmann, MD
(704) 333-7376
200 Queens Rd Ste 400
Charlotte, NC
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Univ Of Cincinnati Coll Of Med, Cincinnati Oh 45267
Graduation Year: 1979
Hospital
Hospital: Rowan Reg Med Ctr, Salisbury, Nc; Carolinas Med Ctr, Charlotte, Nc; Presbyterian Hospital, Charlotte, Nc
Group Practice: Southeast Radiation Oncology Group Matthews Rad Oncology; Southeast Radiation Oncology Group Pa; Southeast Radiation Onco

Data Provided by:
Stephen Paul McClure
(704) 384-4814
200 Hawthorne Lane
Charlotte, NC
Specialty
Hematology

Data Provided by:
Wendy Graham Brick
(704) 302-8000
1025 Morehead Medical Dr
Charlotte, NC
Specialty
Hematology / Oncology

Data Provided by:
Mark Kirsch, MD
(704) 384-4189
PO Box 33549
Charlotte, NC
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Univ Of The Witwatersrand, Med Sch, Johannesburg, So Africa
Graduation Year: 1969
Hospital
Hospital: Rowan Reg Med Ctr, Salisbury, Nc; Presbyterian Hospital, Charlotte, Nc
Group Practice: Southeast Radiation Oncology Group Matthews Rad Oncology; Southeast Radiation Oncology Group Pa; Southeast Radiation Oncology Group Rock Hill Rad Oncology;

Data Provided by:
Heather Dawn Pacholke
(704) 333-7376
200 Queens Rd
Charlotte, NC
Specialty
Radiation Oncology

Data Provided by:
Michael Robert Haake, MD
(704) 333-7376
200 Queens Rd Ste 400
Charlotte, NC
Specialties
Oncology (Cancer), Radiation Oncology, Internal Medicine
Gender
Male
Education
Medical School: In Univ Sch Of Med, Indianapolis In 46202
Graduation Year: 1980
Hospital
Hospital: Rowan Reg Med Ctr, Salisbury, Nc; Carolinas Med Ctr, Charlotte, Nc
Group Practice: Southeast Radiation Oncology Group Matthews Rad Oncology; Southeast Radiation Oncology Group Pa; Southeast Radiation Oncology Group Rock Hill Rad Oncology; Sou

Data Provided by:
James Bryan Hall, MD
(704) 355-8650
PO Box 32861
Charlotte, NC
Specialties
Oncology (Cancer), Gynecological Oncology
Gender
Male
Education
Medical School: Med Univ Of Sc Coll Of Med, Charleston Sc 29425
Graduation Year: 1974

Data Provided by:
Jonathan C Salo
(704) 355-2884
1025 Morehead Medical Dr
Charlotte, NC
Specialty
Surgical Oncology

Data Provided by:
Herman Allen Godwin Jr, MD
(704) 841-1444
PO Box 32861
Charlotte, NC
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Bowman Gray Sch Of Med Of Wake Forest Univ, Winston-Salem Nc 27157
Graduation Year: 1963

Data Provided by:
Data Provided by:

Cancer-Causing Proteins

Provided By:

Scientists are closer to understanding how a recently approved class of antibiotics may work against cancer.

The drugs, called thiazole antibiotics, appear to block a cellular protein called FoxM1, one of the most over-produced proteins in cancer cells, according to researchers at the University of Illinois at Chicago College of Medicine. FoxM1 is believed to play an important role in causing cells to become cancerous and may present a promising target for future anti-cancer treatments.

The researchers also found that thiazoles may inhibit proteasomes, a molecular complex within cells that disposes of old proteins marked for destruction. Recently, a number of proteasome inhibitors have shown promise against cancer. One of these inhibitors, bortezomib (Velcade), has proven effective against a number of cancers, including myeloma and certain forms of lymphoma.

The new research, which appears in the online journal PLoS ONE, points to the possible anti-cancer use of thiazoles in the future. In a university news release, study author Andrei Gartel, an associate professor of molecular genetics, said that by using thiazole antibiotics in combination with well-known proteasome inhibitors, "we may see a synergy that allows us to markedly reduce the dose of any one of these drugs and still effectively kill the cancer cells."

More information

Read more about cancer treatments at the U.S. National Cancer Institute.

SOURCE: University of Illinois at Chicago, news release, Aug. 11, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com