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Cancer-Causing Proteins Durham NC

The drugs, called thiazole antibiotics, appear to block a cellular protein called FoxM1, one of the most over-produced proteins in cancer cells, according to researchers at the University of Illinois at Chicago College of Medicine. FoxM1 is believed to play an important role in causing cells to become cancerous and may present a promising target for future anti-cancer treatments.

Douglas Rivera, MD
Durham, NC
Specialties
Oncology (Cancer)
Gender
Male
Education
Graduation Year: 2007

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O Michael Colvin, MD
(919) 684-4167
Rm 419 Jones Bldg,
Durham, NC
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Oncology (Cancer)
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Male
Education
Graduation Year: 2007

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Carlos M De Castro III, MD
(919) 684-8964
Erwin Road,
Durham, NC
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Oncology (Cancer), Internal Medicine
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Medical School: Univ Of Tx Southwestern Med Ctr At Dallas, Med Sch, Dallas Tx 75235
Graduation Year: 1985
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Hospital: Duke University Med Ctr, Durham, Nc

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Susan L Blackwel, MS
(919) 684-5621
25178 Morris Bldg Box 3198,
Durham, NC
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Oncology (Cancer)
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Male
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Graduation Year: 2007

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Edward Buckley
(919) 620-4467
2100 Erwin Rd
Durham, NC
Specialty
Hematology

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Nicole Larrier, MD
(919) 660-2160
Duke Hospital South Trent Drive,
Durham, NC
Specialties
Oncology (Cancer)
Gender
Male
Education
Graduation Year: 2007

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David Manfield Brizel, MD
(919) 668-5637
PO Box 3085 Science Dr,
Durham, NC
Specialties
Oncology (Cancer), Radiation Oncology
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Male
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Medical School: Northwestern Univ Med Sch, Chicago Il 60611
Graduation Year: 1983
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Hospital: Duke University Med Ctr, Durham, Nc
Group Practice: Duke Univ Med Ctr

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Annick Desjardins, MD
(919) 684-5301
Rm 047 Baker House Trent Dr DUMC 3624,
Durham, NC
Specialties
Oncology (Cancer)
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Male
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Graduation Year: 2007

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David Guy Kirsch
(919) 684-8111
2100 Erwin Rd
Durham, NC
Specialty
Radiation Oncology

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Heather Stuart Shaw, MD
(919) 668-0718
DUMC Box 3381,
Durham, NC
Specialties
Oncology (Cancer)
Gender
Female
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Medical School: Duke Univ Sch Of Med, Durham Nc 27710
Graduation Year: 1993

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Cancer-Causing Proteins

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Scientists are closer to understanding how a recently approved class of antibiotics may work against cancer.

The drugs, called thiazole antibiotics, appear to block a cellular protein called FoxM1, one of the most over-produced proteins in cancer cells, according to researchers at the University of Illinois at Chicago College of Medicine. FoxM1 is believed to play an important role in causing cells to become cancerous and may present a promising target for future anti-cancer treatments.

The researchers also found that thiazoles may inhibit proteasomes, a molecular complex within cells that disposes of old proteins marked for destruction. Recently, a number of proteasome inhibitors have shown promise against cancer. One of these inhibitors, bortezomib (Velcade), has proven effective against a number of cancers, including myeloma and certain forms of lymphoma.

The new research, which appears in the online journal PLoS ONE, points to the possible anti-cancer use of thiazoles in the future. In a university news release, study author Andrei Gartel, an associate professor of molecular genetics, said that by using thiazole antibiotics in combination with well-known proteasome inhibitors, "we may see a synergy that allows us to markedly reduce the dose of any one of these drugs and still effectively kill the cancer cells."

More information

Read more about cancer treatments at the U.S. National Cancer Institute.

SOURCE: University of Illinois at Chicago, news release, Aug. 11, 2009

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