Cancer-Causing Proteins Mooresville NC
Medical School: Univ Of Va Sch Of Med, Charlottesville Va 22908
Graduation Year: 1993
Hospital: St Francis Hosp & Med Ctr, Topeka, Ks; Carolinas Med Ctr, Charlotte, Nc
Internal Medicine, Medical Oncology
Medical School: Univ Of Ms Sch Of Med, Jackson Ms 39216
Graduation Year: 1987
Hematology / Oncology
Oncology (Cancer), Radiation Oncology
Medical School: Bowman Gray Sch Of Med Of Wake Forest Univ, Winston-Salem Nc 27157
Graduation Year: 1978
Hematology / Oncology
Medical School: New York Univ Sch Of Med, New York Ny 10016
Graduation Year: 1960
Internal Medicine, Hematology / Oncology
Scientists are closer to understanding how a recently approved class of antibiotics may work against cancer.
The drugs, called thiazole antibiotics, appear to block a cellular protein called FoxM1, one of the most over-produced proteins in cancer cells, according to researchers at the University of Illinois at Chicago College of Medicine. FoxM1 is believed to play an important role in causing cells to become cancerous and may present a promising target for future anti-cancer treatments.
The researchers also found that thiazoles may inhibit proteasomes, a molecular complex within cells that disposes of old proteins marked for destruction. Recently, a number of proteasome inhibitors have shown promise against cancer. One of these inhibitors, bortezomib (Velcade), has proven effective against a number of cancers, including myeloma and certain forms of lymphoma.
The new research, which appears in the online journal PLoS ONE, points to the possible anti-cancer use of thiazoles in the future. In a university news release, study author Andrei Gartel, an associate professor of molecular genetics, said that by using thiazole antibiotics in combination with well-known proteasome inhibitors, "we may see a synergy that allows us to markedly reduce the dose of any one of these drugs and still effectively kill the cancer cells."
Read more about cancer treatments at the U.S. National Cancer Institute.
SOURCE: University of Illinois at Chicago, news release, Aug. 11, 2009
Copyright © 2009 ScoutNews, LLC. All rights reserved.Read Article at HealthDay.com