Cancer-Causing Proteins Winston Salem NC

The drugs, called thiazole antibiotics, appear to block a cellular protein called FoxM1, one of the most over-produced proteins in cancer cells, according to researchers at the University of Illinois at Chicago College of Medicine. FoxM1 is believed to play an important role in causing cells to become cancerous and may present a promising target for future anti-cancer treatments.

Jason Douglas Huff, MD
(336) 716-4380
Medical Center Blvd,
Winston Salem, NC
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Univ Of Ne Coll Of Med, Omaha Ne 68198
Graduation Year: 2000

Data Provided by:
Denise A Levita, MS
(336) 716-0327
Medical Center Blvd,
Winston Salem, NC
Specialties
Oncology (Cancer)
Gender
Male
Education
Graduation Year: 2007

Data Provided by:
Susan Anitra Melin
(336) 716-2255
Medical Center Blvd
Winston Salem, NC
Specialty
Hematology, Medical Oncology

Data Provided by:
Heather H Shearer
(336) 277-8800
1010 Bethesda Ct
Winston Salem, NC
Specialty
Internal Medicine, Hematology / Oncology

Data Provided by:
David Duane Hurd
(336) 716-2255
Medical Center Blvd
Winston-Salem, NC
Specialty
Internal Medicine, Medical Oncology

Data Provided by:
Frank M Torti
(336) 716-2255
Medical Center Blvd
Winston Salem, NC
Specialty
Medical Oncology

Data Provided by:
Hugh J Wallace
(336) 277-8800
1010 Bethesda Ct
Winston Salem, NC
Specialty
Hematology / Oncology

Data Provided by:
Rolland John Barrett II, MD
(336) 277-8800
1010 Bethesda Ct
Winston Salem, NC
Specialties
Oncology (Cancer), Gynecological Oncology
Gender
Male
Education
Medical School: Univ Of Mi Med Sch, Ann Arbor Mi 48109
Graduation Year: 1979
Hospital
Hospital: Forsyth Mem Hosp, Winston Salem, Nc
Group Practice: Piedmont Hematology Oncology Associates

Data Provided by:
Mary Ann Knovich, MD
(336) 716-7973
Medical Center Blvd,
Winston Salem, NC
Specialties
Oncology (Cancer)
Gender
Female
Education
Medical School: Pa State Univ Coll Of Med, Hershey Pa 17033
Graduation Year: 1996

Data Provided by:
Steven Alan Akman, MD
(336) 716-0230
Medical Center Blvd,
Winston Salem, NC
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: A Einstein Coll Of Med Of Yeshiva Univ, Bronx Ny 10461
Graduation Year: 1975

Data Provided by:
Data Provided by:

Cancer-Causing Proteins

Provided By:

Scientists are closer to understanding how a recently approved class of antibiotics may work against cancer.

The drugs, called thiazole antibiotics, appear to block a cellular protein called FoxM1, one of the most over-produced proteins in cancer cells, according to researchers at the University of Illinois at Chicago College of Medicine. FoxM1 is believed to play an important role in causing cells to become cancerous and may present a promising target for future anti-cancer treatments.

The researchers also found that thiazoles may inhibit proteasomes, a molecular complex within cells that disposes of old proteins marked for destruction. Recently, a number of proteasome inhibitors have shown promise against cancer. One of these inhibitors, bortezomib (Velcade), has proven effective against a number of cancers, including myeloma and certain forms of lymphoma.

The new research, which appears in the online journal PLoS ONE, points to the possible anti-cancer use of thiazoles in the future. In a university news release, study author Andrei Gartel, an associate professor of molecular genetics, said that by using thiazole antibiotics in combination with well-known proteasome inhibitors, "we may see a synergy that allows us to markedly reduce the dose of any one of these drugs and still effectively kill the cancer cells."

More information

Read more about cancer treatments at the U.S. National Cancer Institute.

SOURCE: University of Illinois at Chicago, news release, Aug. 11, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com