Chemo Regimen for Ovarian Cancer Greenville NC

Dose-dense chemotherapy improves survival in women with advanced ovarian cancer, Japanese researchers say. Currently, paclitaxel and carboplatin given every three weeks is considered standard first-line chemotherapy for advanced epithelial ovarian cancer. However, dose-dense weekly treatment with paclitaxel is seen as a way to increase progression-free and overall survival in these patients in Greenville, according to the new study findings.

Gregory Francis Murphy, MD
(252) 752-5077
502 Queen Annes Rd
Greenville, NC
Specialties
Urology
Gender
Male
Education
Medical School: Univ Of Nc At Chapel Hill Sch Of Med, Chapel Hill Nc 27599
Graduation Year: 1989
Hospital
Hospital: Pitt County Memorial Hospital, Greenville, Nc
Group Practice: Eastern Urological Associates Pa

Data Provided by:
Dieter Bruno, MD
(252) 752-5077
1202 Treybrooke Cir
Greenville, NC
Specialties
Urology
Gender
Male
Education
Medical School: Duke Univ Sch Of Med, Durham Nc 27710
Graduation Year: 1995
Hospital
Hospital: Pitt County Memorial Hospital, Greenville, Nc
Group Practice: Eastern Urological Associates Pa

Data Provided by:
Hugh Mallory Reeves
(252) 752-5077
275 Bethesda Drive
Greenville, NC
Specialty
Urology

Data Provided by:
James Richard Gavigan
(252) 752-5077
275 Bethesda Dr
Greenville, NC
Specialty
Urology

Data Provided by:
Caroline Dorothea Ryan
(252) 752-5077
275 Bethesda Dr
Greenville, NC
Specialty
Urology

Data Provided by:
James Richard Gavigan, MD
(252) 752-5077
275 Bethesda Dr
Greenville, NC
Specialties
Urology
Gender
Male
Education
Medical School: Univ Of Ky Coll Of Med, Lexington Ky 40536
Graduation Year: 1967

Data Provided by:
Benjamin Gerald Hines Jr, MD
(252) 752-5077
275 Bethesda Dr
Greenville, NC
Specialties
Urology
Gender
Male
Education
Medical School: Univ Of Nc At Chapel Hill Sch Of Med, Chapel Hill Nc 27599
Graduation Year: 1982

Data Provided by:
Jonathan Harris Taylor
(252) 752-5077
275 Bethesda Dr
Greenville, NC
Specialty
Urology

Data Provided by:
Edward O Janosko II, MD
(252) 752-5077
275 Bethesda Dr
Greenville, NC
Specialties
Urology
Gender
Male
Education
Medical School: Yale Univ Sch Of Med, New Haven Ct 06510
Graduation Year: 1974
Hospital
Hospital: Pitt County Memorial Hospital, Greenville, Nc
Group Practice: Eastern Urological Associates Pa

Data Provided by:
Benjamin Gerald Hines
(252) 752-5077
275 Bethesda Dr
Greenville, NC
Specialty
Urology

Data Provided by:
Data Provided by:

Chemo Regimen for Ovarian Cancer

Provided By:

SUNDAY, Sept. 20 (HealthDay News) -- Dose-dense chemotherapy improves survival in women with advanced ovarian cancer, Japanese researchers say.

Currently, paclitaxel and carboplatin given every three weeks is considered standard first-line chemotherapy for advanced epithelial ovarian cancer. However, dose-dense weekly treatment with paclitaxel is seen as a way to increase progression-free and overall survival in these patients, according to the new study findings.

This phase 3 study of 637 women compared the two approaches. The participants had advanced epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer.

The 320 patients in the conventional regimen group received six cycles of paclitaxel (180 milligrams per meter squared; three-hour intravenous infusion). The 317 patients in the dose-dense group received paclitaxel (80 milligrams per meter squared; one-hour intravenous infusion) on days one, eight and 15. Both groups received carboplatin on day one of a 21-day cycle.

The patients in the dose-dense group had longer median progression-free survival than those in the standard treatment group (28 months versus 17 months), and longer overall survival at three years (72 percent versus 65 percent). This means that women in the dose-dense group had a 29 percent lower risk of cancer progression and a 25 percent lower risk of death, the authors explained.

Toxicity forced 113 patients in the dose-dense group and 69 patients in the conventional therapy group to stop treatment, the researchers noted. Severe anemia occurred in 214 patients (69 percent) in the dose-dense group and in 137 (44 percent) of the standard therapy group.

The survival benefits seen in the dose-dense group are rare in patients with advanced ovarian cancer, and this regimen offers a new treatment option for women with advanced epithelial ovarian cancer, concluded Dr. Noriyuki Katsumata, of the National Cancer Center Hospital in Tokyo, and colleagues.

The study, published in an upcoming print issue of The Lancet, was released online Sunday to coincide with the European Cancer Organization meeting held Sept. 20 to 24 in Berlin.

"The use of such dose-dense therapy should be decided on an individual basis together with other options for women with advanced-stage ovarian cancer," Dr. Michael A. Bookman, of the Arizona Cancer Center in Tucson, wrote in an accompanying commentary in The Lancet.

More information

The U.S. National Cancer Institute has more about ovarian cancer.

SOURCE: The Lancet, news release, Sept. 19, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com