Commercial Genetic Tests Greenville NC

According to Dr. Muin J. Khoury, director of the Office of Public Health Genomics at the U.S. Centers for Disease Control and Prevention, some 1,800 to 2,000 genetic tests have been developed, most of which are relevant only to rare genetic conditions that don't affect too many people.

G Howard Satterfield, MD
(252) 756-8836
PO Box 30946
Greenville, NC
Specialties
Obstetrics & Gynecology
Gender
Male
Education
Medical School: Duke Univ Sch Of Med, Durham Nc 27710
Graduation Year: 1957

Data Provided by:
James Anthony Bofill, MD
(601) 984-5327
Greenville, NC
Specialties
Obstetrics & Gynecology, Maternal & Fetal Medicine
Gender
Male
Education
Medical School: Univ Of Tn, Memphis, Coll Of Med, Memphis Tn 38163
Graduation Year: 1986
Hospital
Hospital: Memorial Hospital At Gulfport, Gulfport, Ms
Group Practice: University Ob/Gyn Associates Pllc

Data Provided by:
Reuben Anderson Clay, MD
111 Breezewood Dr Apt F
Greenville, NC
Specialties
Obstetrics & Gynecology
Gender
Male
Education
Medical School: Univ Of Rochester Sch Of Med & Dentistry, Rochester Ny 14642
Graduation Year: 1964

Data Provided by:
Gwendolyn Knuckles, MD
(252) 830-1035
216 Kineton Cir
Greenville, NC
Specialties
Obstetrics & Gynecology
Gender
Female
Education
Medical School: Tulane Univ Sch Of Med, New Orleans La 70112
Graduation Year: 1984

Data Provided by:
Edward Robson Newton, MD
(252) 744-5695
Department Ob/gyn R
Greenville, NC
Specialties
Obstetrics & Gynecology, Maternal & Fetal Medicine
Gender
Male
Education
Medical School: Loyola Univ Of Chicago Stritch Sch Of Med, Maywood Il 60153
Graduation Year: 1977
Hospital
Hospital: Pitt County Memorial Hospital, Greenville, Nc
Group Practice: Ecu Physicians Brody School Of Medicine

Data Provided by:
Todd Michael Beste, MD
Greenville, NC
Specialties
Obstetrics & Gynecology
Gender
Male
Education
Medical School: Univ Of Mn Med Sch-Minneapolis, Minneapolis Mn 55455
Graduation Year: 1995

Data Provided by:
G Howard Satterfield Jr, MD
(252) 756-8836
PO Box 30946
Greenville, NC
Specialties
Obstetrics & Gynecology
Gender
Male
Education
Medical School: Duke Univ Sch Of Med, Durham Nc 27710
Graduation Year: 1957

Data Provided by:
Christy Michelle Isler, MD
(252) 816-2344
600 Moye Boulevard Brody Outpatient Center
Greenville, NC
Specialties
Obstetrics & Gynecology, Maternal & Fetal Medicine
Gender
Female
Education
Medical School: Univ Of Louisville Sch Of Med, Louisville Ky 40202
Graduation Year: 1994

Data Provided by:
D E Darnell Jones, MD
(252) 816-5695
600 Moye Blvd Dept Obg
Greenville, NC
Specialties
Obstetrics & Gynecology
Gender
Male
Education
Medical School: Duke Univ Sch Of Med, Durham Nc 27710
Graduation Year: 1968

Data Provided by:
Andrew Haven
(252) 757-3131
2251 Stantonsburg Rd
Greenville, NC
Specialty
Obstetrics & Gynecology

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Commercial Genetic Tests

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WEDNESDAY, Oct. 14 (HealthDay News) -- Peter Orszag, the 40-year-old head of the White House Office of Management and Budget, is reported to drink so much tea, hot and iced, that he took a genetic test to see if his body could metabolize his voluminous intake of caffeine.

According to the results, his body is perfectly suited to the task, and Orszag can easily go about his busy day, according to published reports.

Like Orszag, droves of people are flocking to get genetic tests -- which are now marketed direct-to-consumer -- ranging from the $179 CaffeineGen to assess caffeine metabolism to those that claim to gauge risk for Alzheimer's disease. There's also a $79 HomeDNA Home Paternity Testing System that includes, for an additional $25, lab services for the "alleged" father and one child.

But whether or not the commercially available genetic tests currently entering the market actually provide any useful information is another question.

According to Dr. Muin J. Khoury, director of the Office of Public Health Genomics at the U.S. Centers for Disease Control and Prevention, some 1,800 to 2,000 genetic tests have been developed, most of which are relevant only to rare genetic conditions that don't affect too many people.

"A growing number of these tests are suggested to be used to target interventions [pharmacogenetics], and to do early detection or susceptibility testing," Khoury said.

Khoury participated in a recent conference hosted by the National Academy of Sciences in Washington, D.C., that looked at direct-to-consumer marketing of genetic tests. Among other things, panelists discussed how valid and useful these tests are. Probably some will prove useful, and some will not, the experts said.

"With very few exceptions, we still have some big gaps in evidence," said Dr. Marc S. Williams, director of clinical genetics at the American College of Medical Genetics and director of Intermountain Healthcare, Clinical Genetics Institute, in Salt Lake City. "Do we really know if this works or not?"

"We don't know what they do to help people or hurt them," Khoury added.

Some are tried and true, such as those to detect the BRCA 1 and 2 genes, which heighten a woman's risk for breast and ovarian cancer, or specific tests to figure the risk for Lynch syndrome, a hereditary form of colon cancer.

But take the example of several much-hyped genetic tests to help determine what type or what dose of antidepressant would be effective for different individuals.

"Researchers have found that even clinically available tests that are supposed to inform someone about specific doses or specific medications use virtually no evidence. We don't even know what to do with the results of tests in terms of dosing, etcetera," Williams said. "People are promoting this test to choose which SSRI [selective serotonin reuptake inhibitor] they should use and at what dose with almost no evidence. We'd love to be able to predict which drug to use, but the evidence just isn't there to support that."

And results could be alarming to some people, said Sandra Soo-Jin Lee, senior research scholar and medical anthropologist at the Stanford University Center for Biomedical Ethics, although one recent study reported that people who discovered they had a higher risk for Alzheimer's through a genetic test were not psychologically distressed by the results.

Perhaps they kept in mind that genes are only one factor that determine risk. The environment also has a lot to do with it.

For instance, "there is a fairly robust history of research around genetic variations a population might express in terms of how they take up those chemicals. So, in terms of caffeine metabolism, there may be some individuals that are fast metabolizers of caffeine so it goes through their system fairly quickly," Lee said.

"But there may also be other things about that person and that person's environment that affect how they metabolize caffeine. For now, we just don't know what's what in terms of tests and results," she added.

"Right now, the direct-to-consumer genetic testing companies are working in an unregulated space. It's sort of a no man's land," Lee said. "But I think there are some indications that we are moving in a direction of creating some hopeful policies. One of the first steps is making sure all the stakeholders come together and discuss what would be helpful in terms of regulation. That not only means health-care providers and patients, but companies themselves."

Attempts by HealthDay to reach several makers of the tests for comment were unsuccessful.

More information

The U.S. National Library of Medicine has more on genetic testing.

Author: By Amanda Gardner
HealthDay Reporter

SOURCES: Muin J. Khoury, M.D., Ph.D., director, Office of Public Health Genomics, U.S. Centers for Disease Control and Prevention, Atlanta; Marc S. Williams, M.D., director, clinical genetics, American College of Medical Genetics, and director, Intermountain Healthcare, Clinical Genetics Institute, Salt Lake City, Utah; Sandra Soo-Jin Lee, Ph.D., senior research scholar and medical anthropologist, Stanford University Center for Biomedical Ethics, Palo Alto, Calif.; March 27, 2009, The New York Times

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