Gene Mutation and Endometrial Cancer Jacksonville NC

A genetic marker for aggressive endometrial cancer has been identified by U.S. researchers, who said their finding could lead to more targeted and risk-appropriate treatments. The researchers, from the Washington University School of Medicine in St. Louis, found that genetic mutation of the ATR gene in tumors boosts the risk of cancer recurrence and death in women#r3 with a highly aggressive form of the disease known as endometrioid endometrial cancer.

Gregory Dean Streeter
(910) 353-0565
200 Doctor Dr
Jacksonville, NC
Specialty
Family Practice

Data Provided by:
Sarah E Ahrens
(910) 577-2360
317 Western Blvd
Jacksonville, NC
Specialty
Internal Medicine

Data Provided by:
Elizabeth K Thomas, MD
(910) 455-8428
138 Winter Rd
Jacksonville, NC
Specialties
General Practice
Gender
Female
Education
Medical School: Univ Of Md Sch Of Med, Baltimore Md 21201
Graduation Year: 2001

Data Provided by:
Marshall Brantley Frink, MD
Jacksonville, NC
Specialties
General Practice
Gender
Male
Education
Medical School: Bowman Gray Sch Of Med Of Wake Forest Univ, Winston-Salem Nc 27157
Graduation Year: 1981

Data Provided by:
Ruth W Guyer
(910) 353-4991
217 Station St
Jacksonville, NC
Specialty
Family Practice

Data Provided by:
Eusebio Chiong Desuyo
(910) 455-9398
3652 Henderson Dr
Jacksonville, NC
Specialty
Internal Medicine, Pulmonary Disease, Critical Care (Intensivists)

Data Provided by:
Hong-Yill Chung, MD
(910) 353-2800
PO Box 12134
Jacksonville, NC
Specialties
General Practice
Gender
Male
Education
Medical School: Korea Univ Coll Of Med, Chong-No-Ku, Seoul, So Korea
Graduation Year: 1969

Data Provided by:
Harry Schnee Messec
(910) 346-2273
308 Dolphin Dr
Jacksonville, NC
Specialty
Family Practice

Data Provided by:
Jose Larrabaster Ros
(910) 937-0008
3245 Henderson Dr
Jacksonville, NC
Specialty
Internal Medicine

Data Provided by:
Adnan Taj-Eldin
(910) 353-6327
200 Doctors Dr
Jacksonville, NC
Specialty
Internal Medicine

Data Provided by:
Data Provided by:

Gene Mutation and Endometrial Cancer

Provided By:

WEDNESDAY, May 27 (HealthDay News) -- A genetic marker for aggressive endometrial cancer has been identified by U.S. researchers, who said their finding could lead to more targeted and risk-appropriate treatments.

The researchers, from the Washington University School of Medicine in St. Louis, found that genetic mutation of the ATR gene in tumors boosts the risk of cancer recurrence and death in women with a highly aggressive form of the disease known as endometrioid endometrial cancer.

The ATR gene directs cellular responses to DNA damage, the researchers noted.

"Women whose endometrial cancers have an ATR mutation have more than four times the risk of having their cancer return," study author Dr. Israel Zighelboim, a gynecologic oncologist, said in a news release from the university. "This and similar tumor biomarkers could potentially identify those patients most in danger of recurrence and guide the development of treatments aimed at these more aggressive tumors."

ATR mutations were found in about 5 percent of the 248 endometrioid endometrial tumor samples analyzed by the researchers. Women with ATR mutations were 4.29 times more likely to have the cancer recur after treatment and 3.88 times more likely to die.

The study appears online in the Journal of Clinical Oncology.

Zighelboim and his research colleagues plan to see if the prognostic value of ATR mutations can be confirmed in a larger group of women and to investigate the association between ATR mutations and treatment response after cancer recurrence.

More information

The American Cancer Society has more about endometrial cancer.

SOURCE: Washington University School of Medicine in St. Louis, news release, May 26, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com