Gene Mutation and Endometrial Cancer Mooresville NC
General Practice, Family Practice
Insurance Plans Accepted: For your convenience, we gladly file insurance for our patients.
Medicare Accepted: Yes
Accepts Uninsured Patients: Yes
Emergency Care: Yes
Residency Training: 2 years clinical at Sherman College Health Center, Spartanburg, SC
Medical School: Life University College of Chiropractic and Sherman College of Straight Chiropractic, 2004
Awards: Past president of Sherman College Sacro Occipital Technique Club
Languages Spoken: English,Spanish
General Practice, Obstetrics & Gynecology
Gene Mutation and Endometrial Cancer
WEDNESDAY, May 27 (HealthDay News) -- A genetic marker for aggressive endometrial cancer has been identified by U.S. researchers, who said their finding could lead to more targeted and risk-appropriate treatments.
The researchers, from the Washington University School of Medicine in St. Louis, found that genetic mutation of the ATR gene in tumors boosts the risk of cancer recurrence and death in women with a highly aggressive form of the disease known as endometrioid endometrial cancer.
The ATR gene directs cellular responses to DNA damage, the researchers noted.
"Women whose endometrial cancers have an ATR mutation have more than four times the risk of having their cancer return," study author Dr. Israel Zighelboim, a gynecologic oncologist, said in a news release from the university. "This and similar tumor biomarkers could potentially identify those patients most in danger of recurrence and guide the development of treatments aimed at these more aggressive tumors."
ATR mutations were found in about 5 percent of the 248 endometrioid endometrial tumor samples analyzed by the researchers. Women with ATR mutations were 4.29 times more likely to have the cancer recur after treatment and 3.88 times more likely to die.
The study appears online in the Journal of Clinical Oncology.
Zighelboim and his research colleagues plan to see if the prognostic value of ATR mutations can be confirmed in a larger group of women and to investigate the association between ATR mutations and treatment response after cancer recurrence.
The American Cancer Society has more about endometrial cancer.
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