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Genes and Testicular Cancer Cary NC

U.S. scientists say they've identified key gene variants tied to an increased risk of testicular cancer in Cary. They said the findings are an important step toward understanding which men are at high risk for the disease.

Kildaire Animal Medical Center
(919) 469-8086
1409 Kildaire Farm Rd.
Cary, NC

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Chiropractic Partners
(919) 467-7797
1125 Kildaire Farm Rd
Cary, NC

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Cat Clinic Of Cary
(919) 469-9000
2464 SW Cary Pkwy
Cary, NC

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Milham Family Chiropractic
(919) 238-7540
900 W Williams St
Apex, NC

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Roger B. Russell
(919) 785-0505
3633 Harden Road
Raleigh, NC
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Mudryk Family-Chiropractic, PA
(919) 238-7736
401 Keisler Dr. Suite 100
Cary, NC

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Team Chiropractic & Sports Medicine - Cary
(919) 650-2447
258 Towne Village Drive
Cary, NC

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Mayfair Animal Hospital
(919) 467-6146
1130 SW Maynard Rd
Cary, NC

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Chiropractic First Pllc
(919) 443-1851
1011 West Williams St. Ste 104
Apex, NC

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Glenn M Davis
(919) 785-1220
2304 Wesvill Court
Raleigh, NC
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Genes and Testicular Cancer

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MONDAY, June 1 (HealthDay News) -- U.S. scientists say they've identified key gene variants tied to an increased risk of testicular cancer.

They said the findings are an important step toward understanding which men are at high risk for the disease.

"Despite being quite heritable, there really have not been any clear genetic risk factors that can account for most cases of testicular cancer. These variants are the first striking genetic risk factors found for this disease to date," Dr. Katherine L. Nathanson, an assistant professor of medicine at the University of Pennsylvania School of Medicine and a specialist in medical genetics at the Abramson Cancer Center, said in a news release.

Nathanson and colleagues found that men with two copies of the common version of the c-KIT ligand (KITLG) gene are 4.5 times more likely to develop testicular cancer than men with two copies of the less common versions of the gene.

The researchers also found that men with two copies of the common version of variants next to another gene called sprouty 4 (SPRY4) are almost 1.5 times more likely to develop testicular cancer than men with two copies of the less common version of the gene.

The study appears online in the journal Nature Genetics.

Environmental exposure has been suspected as a factor in the growing incidence of testicular cancer, which is the most common cancer among young men, the study authors note. This study shows that genes also play a major role in a man's risk of developing the disease.

"This finding is quite different than those observed in many other genome-wide association studies," Nathanson said. "In most studies, the increased risk of disease is associated with the less common variant of the gene. In this case, it is the more common variant in Caucasians that is associated with risk. If you carry two copies of the less common variant you are probably at incredibly low risk."

More information

The American Cancer Society has more about testicular cancer.

SOURCE: University of Pennsylvania School of Medicine, news release, May 31, 2009

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