Melanoma Vaccine Concord NC

A vaccine for advanced melanoma has shown promise in a new study. Melanoma is the most serious type of skin cancer in Concord. The five year-survival rates for local and metastatic melanoma are 65 percent and 16 percent, respectively. In 2009, an estimated 69,000 people in the United States will be diagnosed with melanoma and about 8,600 will die of the disease, according to the American Cancer Society.

Modern Eye Care
(704) 792-2777
Vining St. NW
Concord, NC

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English Chiropractic
(704) 353-7365
5344 Central Ave
charlotte, NC

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Duncan Chiropractic
(704) 987-5050
19824 W Catawba Ave # E
Cornelius, NC

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ChiroMed Plus
(704) 341-5200
6401 Carmel Rd.
Charlotte, NC

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Modern Eye Care - Eye Exams Only
(760) 792-2777
223 Faith Road
Salisbury, NC

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Pai Clinic of Chiropractic & Sports Medicine
(704) 599-0900
8821 University East Dr #100
Charlotte, NC

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Family First Chiropractic
(704) 545-7700
7316 Matthews Minthill Rd
Charlotte, NC

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Galen Grayson, MD
(704) 295-0001
817 E Morehead St
Charlotte, NC
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Genesis Eye Center
Specialties
Ophthalmology

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Vincent Voci
(704) 333-8300
2620 East 7th Street
Charlotte, NC
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Cosmetic Surgery
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Uhrich Chiropractic
(704) 353-7529
816 Brawley School Rd # D
Mooresville, NC

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Melanoma Vaccine

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SATURDAY, May 30 (HealthDay News) --A vaccine for advanced melanoma has shown promise in a new study.

Melanoma is the most serious type of skin cancer. The five year-survival rates for local and metastatic melanoma are 65 percent and 16 percent, respectively. In 2009, an estimated 69,000 people in the United States will be diagnosed with melanoma and about 8,600 will die of the disease, according to the American Cancer Society.

The study, a phase 3 clinical trial involving 185 people, found that using the peptide vaccine in combination with the immunotherapy drug Interleukin-2 improved response rates and progression-free survival, according to University of Texas M.D. Anderson Cancer Center researchers, who said it was the first phase 3 trial to show a clinical benefit in a vaccine for melanoma.

Response rate and progression-free survival were 22.1 percent and 2.9 months, respectively, in people given the vaccine, compared with 9.7 percent and 1.6 months for those who were not vaccinated. Median overall survival was 17.6 months for the vaccine group and 12.8 months for the others.

The study, which was to be presented Saturday at the annual meeting of the American Society of Clinical Oncology in Orlando, Fla., was funded in part by Novartis, which makes Interleukin-2.

"Obviously this is a disease, in its advanced setting, in need of better therapies for our patients," study co-author Dr. Patrick Hwu, a professor and chairman of M.D. Anderson's Department of Melanoma Medical Oncology, said in a news release from the center.

"While more follow-up is needed, this study serves as a proof-of-principle for vaccines' role in melanoma and in cancer therapy overall," Hwu said. "If we can use the body's own defense system to attack tumor cells, we provide a mechanism for ridding the body of cancer without destroying healthy tissue."

The vaccine, called gp100:209-217 (200M), works by stimulating T-cells, which control immune response.

"This vaccine activates the body's cytotoxic T-cells to recognize antigens on the surface of the tumor," Hwu said. "The T-cells then secrete enzymes that poke holes in the tumor cell's membrane, causing it to disintegrate."

More information

The Skin Cancer Foundation has more about melanoma.

SOURCE: University of Texas M.D. Anderson Cancer Center, news release, May 30, 2009

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